|Statement||organized and edited by T. W. Goodwin.|
|Series||Biochemical Society symposia no. 27|
|Contributions||Krebs, Hans Adolf, Sir., Goodwin, T. W. ed., Biochemical Society (Great Britain)|
|LC Classifications||QP801.C63 M4|
|The Physical Object|
|Pagination||ix, 144 p.|
|Number of Pages||144|
|LC Control Number||68017671|
Fig. 1 Overview of the roles of citrate and aconitases in. the major energy metabolism pathways. Citrate is a key. intermediate that interconnects the metabolic pathways of. the citric acid cycle and oxidative phosphorylation in the. mitochondria to glycolysis and fatty acid synthesis in the. Niamh C. Williams, Luke A. J. O’Neill, A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation, Frontiers in Immunology, /fimmu, 9, ().Cited by: adshelp[at] The ADS is operated by the Smithsonian Astrophysical Observatory under NASA Cooperative Agreement NNX16AC86A. Overview of the roles of citrate and aconitases in the major energy metabolism pathways. Citrate is a key intermediate that interconnects the metabolic pathways of the citric acid cycle and.
Abstract. The citric acid cycle is the final common oxidative pathway for carbohydrates, fats and amino acids. It is the most important metabolic pathway for the energy supply to the body. TCA is the most important central pathway connecting almost all the individual metabolic pathways. In this review article, introduction, regulation and energetics of TCA cycle have been discussed. We conclude that mitochondrial ACO3 predominates in citrate metabolism in establishing seedlings, but the roles each play in seedling carbon metabolism remain poorly defined. The publisher has kindly granted permission to reproduce this abstract on TAIR. Citrate (C 6 H 7 O 7) is a small negatively charged molecule with a molecular weight of Daltons. In aerobic organisms, citric acid is an intermediate in the Kreb's cycle, a mitochondrial metabolic pathway involved in the chemical conversion of carbohydrates, fats and proteins to generate ATP. The mitochondrial citrate carrier: metabolic role and regulation of its activity and expression. IUBMB L – /iub ; Guarente L. (). Mitochondria—a nexus for aging, calorie restriction, and sirtuins? Cell , – / [PMC free article].
The central and regulating role of citrate. Citrate inhibits PFK1, PK, PDH and SDH, and these inhibitions allow an immediate adjustment of glycolysis and TCA cycle fluxes, adapted to ATP production. Concurrently, citrate stimulates gluconeogenesis (through F1,6BPase) and lipid synthesis through ACC. Moreover, CIC serves multiple functions: 1) transporting cis-aconitate, threo-isocitrate, phosphoenolpyruvate, L-malate as well as succinate ; 2) catalyzing phosphoenolpyruvate, an intermediate of gluconeogenesis, exit from mitochondria to cytosol for the synthesis of glucose ; 3) providing NAD(P)H for lipogenesis or nicotinamide adenine dinucleotide (NAD+) for glycolysis; 4) Author: Ruyi Peng, Meng Zhang, Haizhou Wang, Jun Lin, Hongling Wang, Fan Wang, Lan Liu, Qiu Zhao, Jing Liu. Citrate serves as a key metabolite in the tricarboxylic acid cycle (TCA cycle, also referred to as the Krebs cycle) and plays an important intermediary role in many metabolic pathways in both. The Role of INDY in Metabolic Regulation. Item Preview remove-circle mainly handling the uptake of citrate via the plasma membrane into the cytosol. Deletion of mINDY in mice leads to significant metabolic changes akin to caloric restriction, likely caused by reducing the effects of mINDY-imported citrate on fatty acid and cholesterol.